"support for the use of selective factor Xa inhibitors J. A. Caprini - Phlebolymphology - 2007; 14 (1): 17 Pharmacological treatment of chronic venous disorders M. Perrin and G. Geroulakos - Phlebolymphology - 2007; 14 (1): 23 Popliteal vein entrapment: an unrecognized cause of failure in surgery for superficial venous insufficiency R. Milleret - Phlebolymphology - 2007; 14 (1): 31 BOOK REVIEW A Review by J. J. Bergan A Review by M. Perrin A Review by J. J. Bergan "

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" statementprovides recommendations that will profoundly impact the design, conduct, and reporting of new drug trials. Additionally, registration of all trials in a public repository ensures that every trial becomes part of the public record, allowing clinicians to explore the full range of clinical evidence. Finally, QUORUM addresses standards for improving the quality of reporting meta-analyses of randomized, controlled, clinical trials. These improvements in the reporting of trials will strengthen evidence-based medicine guidelines. Evidence-based medicine guidelines have resulted in accepte"

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"of Engineering and Applied Sciences, Evanston, IL, USA ABSTRACT Over the past decade, a number of new anticoagulant compounds have been developed, including the low-molecular-weight heparins (LMWHs) and the factor Xa inhibitors fondaparinux and idraparinux. Factor Xa inhibitors are powerful anticoagulants that act by producing a reversible conformational change in the antithrombin III molecule. Unlike unfractionated heparin and warfarin, these new compounds, which have a linear pharmacokinetic profile, do not require frequent patient monitoring. Factor Xa inhibition has been studied in t"

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"where clinical signs suggest its presence. These are: edema related to position, cramps associated with prolonged standing, exertional pain together with cramps and swelling of the calf muscle in athletes, and asymmetry of the circumference of the anterior and posterior tibialis muscles. The most frequent circumstances in which this condition is detected are: • intensive muscle-building training in young women who practice highrisk sports; • repeated recurrence of varicose veins in the area supplied by the short saphenous vein; • recurrent sural vein thrombosis outside of any context"

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", UK The term chronic venous disorder (CVD) is used to denote all abnormal clinical changes that result from venous disease of the lower extremities, and that have a chronic course.1 According to this definition, CVD includes patients who present with so-called symptoms and/or signs of venous disease that characterize each class of CVD in the Clinical, Etiological, Anatomical, Pathophysiological (CEAP) classification,2 from class C0s to class C6. A review of the literature3 shows that CVD is most commonly manifested by the following symptoms: heaviness in the legs, pain, a sensation of s"

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"ommon, no recent book deals exclusively with this subject. This book brings under one cover the opinions of 25 physicians, most of whom have published heavily in British and international journals. Collectively, they have contributed clearly formulated chapters on primary varicose veins, management of recurrent varicose veins, quality of life, in addition to essays on symptomatology, history, and epidemiology. Altogether, very good and complete coverage of a very important subject. A single American surgeon, Joseph Caprini of Northwestern University, enters this august company. He has cont"

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" how to conduct and report new drug trials, and gives an overview on the state of the art of how to treat patients with venous thromboembolism, based on recommendations from consensus papers. Colleagues, who are planning randomized controlled trials, will find very important suggestions that will help to improve the quality of their studies. An update on the use of factor Xa inhibitors for thrombosis prevention and treatment comes from Joseph Caprini, a top expert in the field of thromboprophylaxis. Until now, neither HIT (heparin-induced thrombopenia) nor osteoporosis has been observed"

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"ges in the skin and subcutaneous tissues of the lower leg. Subjects with truncal varices are not classified as CVI unless they have corona phlebectatica, lipodermatosclerosis, or open ulceration.” The term “insufficiency” deserves a clear-cut definition. It usually refers to the failure of an organ or of a given function. So, valvular insufficiency can be denoted as venous valve failure, and venous insufficiency as a venous system incompetence (superficial, deep, or perforator insufficiency for incompetence in, respectively, the superficial, deep or, perforating veins). A given patient m"

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" chronic venous disease, this increase in venous pressure is linked to venous reflux. A linear relationship exists between increased ambulatory venous pressure and skin ulceration. The length of time a subject is exposed to elevated venous pressure is a major factor in the progression of venous disease and in the development of varicose veins. The development of an animal model of venous hypertension (VHT) has demonstrated venous valve damage at an early stage of the disease, associated with the development of a leukocyte-endothelium biochemical cascade reaction. According to a similar mech"

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" B. Eklof N Engl J Med. 2006;355:488-498. (2006 Massachusetts Medical Society ISSN-0028-4793 Web site: www.nejm.org) We are pleased to see publication of an article on venous disease in one of the most prestigious reference medical journals. It is an article designed to improve our understanding of the mechanisms that lead to chronic venous disease, and its excellent quality is to be expected considering the authors. Problem position: An epidemiological approach was required to correctly position the problem. The Edinburgh study1 was used as the reference, the rationale being the good "

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