"ificant impact on patients’ quality of life. But for the clinician as well as the researcher, pain in venous disease is difficult to assess, both because of its multifaceted nature and due to the absence of a close relationship between pain as a symptom and the severity of venous disease. Current hypotheses on the mechanisms of pain in venous disease emphasize a local inflammatory origin. However, although indicators suggesting an inflammatory reaction in varicose veins have accumulated dramatically over the last five years, the precise mechanisms governing the interaction between the mediat"

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"se research, the aim of which is to establish a cause that will allow us to prevent or at least slow down this undesirable process. We have investigated the role played by inflammatory cells, especially leukocytes, in the etiology of varicose veins. We hypothesize that venous insufficiency could result from the interaction between two processes: tissue aging and abnormalities in the leukocyte/endothelial cell interaction. These two processes, the individual contribution of which depends on the context, are believed to compound each other resulting in venous insufficiency. Thus, in young indivi"

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