"h specialists and general practitioners have to deal with this disease, there is a need for practical support regarding CVD management in daily practice. This article summarizes the most recent guidelines regarding the place of venoactive drugs (VADs) such as Daflon 500 mg in the management of this disease. In addition, it makes suggestions regarding expected improvements in future guideline documents. INTRODUCTION Chronic venous disease (CVD) of the lower limbs is often characterized by symptoms and signs as a result of structural or functional abnormalities of the veins. Symptoms include"