"n the net transcapillary filtration rate exceeds the lymphatic drainage rate over a period of time. In other words, increased filtration or reduced lymph flow or both. The present chapter focuses on the lower limb edema frequently associated with venous insufficiency. Because the key pathophysiological factor behind this edema is increased distal venous pressure in the upright position, much attention is given to the mechanisms leading to venous hypertension. Furthermore, because understanding edema mechanisms requires knowledge of the factors acting on transcapillary fluid balance, a basic re"

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