Course duration for venoactive-drug treatment in chronic venous disease

Roman KALININ, MD, PhD, DMedSc; Igor SUCHKOV, MD, PhD, DMedSc; Aleksey KAMAEV, MD, PhD; Nina MZHAVANADZE, MD, PhD. MD Department of Cardiovascular, Endovascular, Operative Surgery and Topographic Anatomy, Ryazan State Medical University, Ryazan, Russia Abstract Chronic venous disease (CVD) is currently the most common vascular disorder of the lower extremities. The gradual progression of CVD has a negative impact on patients and also leads to high economic costs of medical care, especially for the advanced forms of chronic venous insufficiency (CVI). Conservative management of CVD includes the use of compression stockings and pharmacological therapy. Despite the efficacy of compression therapy,…

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Risks and contraindications of medical compression treatment

Eberhard RABE, MD1; Felizitas PANNIER, MD2 1Private practice, Helmholtzstr. 4, Bonn, Germany 2Private practice, Helmholtzstr. 4, Bonn, Germany and Department of Dermatology, University of Cologne, Germany Background Medical compression treatment with medical compression stockings (MCS), compression bandages (CB), or intermittent pneumatic compression (IPC) belongs to the basic treatment options in acute and chronic venous diseases and in lymphedema. In a recent international consensus paper, well-known experts in the field reviewed the recent literature on reported risks and recommended contraindications for elastic compression treatment. Results: Reported nonsevere adverse events (AEs) included skin irritation, allergic skin reaction, discomfort and pain, forefoot edema…

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Effectiveness of micronized purified flavonoid fraction–based conservative treatment in chronic venous edema

Vadim Yu BOGACHEV, MD, PhD On behalf of the VAP-PRO-C3 study investigators group. Department of Faculty Surgery No. 2, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia Abstract Aim: This study assessed the effectiveness of micronized purified flavonoid fraction (MPFF)-based conservative treatment in patients with chronic venous edema (CVE) as part of an observational program that evaluated the management of patients with CVE caused by the primary forms of chronic venous disease (CVD) in real clinical practice. Materials and methods. The VAP-C3 (Vein Act Prolonged-C3; NCT03722836) prospective, single-arm, observational study was conducted in Russia in adult outpatients with CVD…

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Edema in venous insufficiency

Einar STRANDEN Section of Vascular Investigations Oslo Vascular Centre Oslo University Hospital, Aker ABSTRACT Edema is a clinical state characterized by an accumulation of fluid in the interstitial or intracellular space. This accumulation develops when the net transcapillary filtration rate exceeds the lymphatic drainage rate over a period of time. In other words, increased filtration or reduced lymph flow or both. The present chapter focuses on the lower limb edema frequently associated with venous insufficiency. Because the key pathophysiological factor behind this edema is increased distal venous pressure in the upright position, much attention is given to the mechanisms leading…

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