Edema in venous insufficiency

Einar STRANDEN Section of Vascular Investigations Oslo Vascular Centre Oslo University Hospital, Aker ABSTRACT Edema is a clinical state characterized by an accumulation of fluid in the interstitial or intracellular space. This accumulation develops when the net transcapillary filtration rate exceeds the lymphatic drainage rate over a period of time. In other words, increased filtration or reduced lymph flow or both. The present chapter focuses on the lower limb edema frequently associated with venous insufficiency. Because the key pathophysiological factor behind this edema is increased distal venous pressure in the upright position, much attention is given to the mechanisms leading…

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